CryoNAV About: Difference between revisions
Created page with "=About CryoNAV= '''CryoNAV''' is a comprehensive data management software platform designed specifically for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) workflows. Developed by the Navarro Lab at the University of Lausanne (UNIL), CryoNAV provides researchers with an integrated solution for managing the complete lifecycle of cryo-EM data, from initial sample preparation through final data archiving. ==Overview== CryoNAV addresses the comp..." |
No edit summary |
||
| Line 72: | Line 72: | ||
* Academic cryo-EM facilities | * Academic cryo-EM facilities | ||
* Core imaging centers | * Core imaging centers | ||
* Collaborative research projects | * Collaborative research projects | ||
* Training and educational programs | * Training and educational programs | ||
Revision as of 23:42, 20 June 2025
About CryoNAV
CryoNAV is a comprehensive data management software platform designed specifically for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) workflows. Developed by the Navarro Lab at the University of Lausanne (UNIL), CryoNAV provides researchers with an integrated solution for managing the complete lifecycle of cryo-EM data, from initial sample preparation through final data archiving.
Overview
CryoNAV addresses the complex data management challenges faced by cryo-EM facilities and research laboratories by offering a unified platform that streamlines workflows, ensures data integrity, and facilitates collaboration. The software is built with the understanding that cryo-electron tomography is a structural biology method that can determine the molecular architecture of cellular components and macromolecules in their native biological context.
Key Features
Sample and Experiment Management
- Comprehensive tracking of sample preparation conditions
- Experimental parameter recording and management
- Protocol standardization and documentation
Data Collection and Import
- Automated tilt series data import from microscope servers
- Real-time data retrieval and organization
- Support for multiple data collection schemes
Metadata Management
- Centralized metadata storage and organization
- Standardized annotation systems
- Cross-referencing capabilities between experiments
Grid Visualization and Mapping
- Interactive grid maps and thumbnails
- Location-based tilt series organization
- Visual tracking of data collection progress
- Search functionality for specific grid locations
Data Processing Integration
CryoNAV integrates with leading cryo-EM processing tools including:
- IMOD - Image processing and 3D reconstruction
- Dynamo - Subtomogram averaging (the lab contributes to the software package Dynamo for subtomogram averaging)
- CryoCARE - Content-aware image restoration
- DeepDeWedge - Missing wedge restoration using deep learning
- CTFfind - Contrast transfer function estimation
- And many other specialized cryo-EM tools
Storage and Backup
- Automated data storage management
- Redundant backup systems
- Long-term storage (LTS) integration
- Data integrity verification
Sharing and Archiving
- Upload capabilities to online repositories and databases
- Cataloguing systems for easy data retrieval
- Long-term archiving solutions
- Collaboration tools for multi-user access
Development Background
CryoNAV was developed by the Navarro Lab, which applies and advances cryo-electron tomography technologies to image cellular samples. The lab's expertise in implementing and developing computational tools for cryo-electron tomographic data processing and subtomogram averaging directly informs CryoNAV's design and functionality.
The software addresses the lab's mission to build computational strategies for quantitative analysis of 3D volumes and in situ structure determination, extending these capabilities to the broader cryo-EM community through an accessible data management platform.
Technical Specifications
CryoNAV is designed to handle the demanding requirements of modern cryo-EM facilities:
- Support for high-throughput data collection workflows
- Scalable storage architecture
- Web-based interface for remote access
- Multi-user concurrent access capabilities
- Integration APIs for third-party tools
- Cross-platform compatibility
Applications
CryoNAV is particularly well-suited for:
- Academic cryo-EM facilities
- Core imaging centers
- Collaborative research projects
- Training and educational programs
The software supports both single-particle analysis and cryo-electron tomography workflows, making it versatile for various research applications in structural biology.
Support and Documentation
For installation guides, tutorials, and technical support, please refer to the other sections of this wiki:
Contact
For more information about CryoNAV or to discuss implementation at your facility, please contact the development team through the Navarro Lab at UNIL.